Fill in the blank with the appropriate word: It will take a lot more than that to make _____ run that far.

In this sentence, the correct choice is "me" because it serves as the object of the verb "make." In English, when a pronoun follows a verb and indicates the recipient of an action, it should be in the objective case. In this context, "make me run" is grammatically correct since "me" is the object that is being affected by the action of running.

To clarify further, "I" would be incorrect here as it is a subject pronoun, which is used when the pronoun is the subject of the verb, not the object. Similarly, "we" and "us" are subject and object pronouns for the first-person plural, respectively. "Us" could technically work in an informal context, but "make us run" would imply that it is multiple people being made to run, which changes the meaning from a singular action directed at one person. Thus, "me" is the choice that correctly fits the sentence structure and intent.